Injectable Polymeric Biopharmaceutical Formulations

An injectable pharmaceutical composition comprising:

• particles, the particles comprising:
• a biopharmaceutical agent;
• and
• a polyacrylamide-based copolymer comprising:
• a water-soluble carrier monomer selected from N-(3-methoxypropyl)acrylamide (MPAM), 4-acryloylmorpholine (MORPH), N,N-dimethylacrylamide (DMA), N-hydroxyethyl acrylamide (HEAM), acrylamide (AM), and combinations thereof;
• and
• a functional dopant monomer selected from N-[tris(hydroxymethyl)-methyl]acrylamide (TRI), 2-acrylamido-2-methylpropane sulfonic acid (AMP), (3-acrylamidopropyl)trimethylammonium chloride (TMA), N-isopropylacrylamide (NIP), N—N-diethylacrylamide (DEA), N-tert-butylacrylamide (TBA), N-phenylacrylamide (PHE), and combinations thereof;
• and
• a liquid carrier in which the particles are suspended, wherein the liquid carrier is selected from triacylglyceride, diacylglyceride, monoacylglyceride, an acetamide, alkyl alcohol, aryl alcohol, aralkyl alcohol, fatty acid, fatty acid ester, oil, alkane, perfluoroalkane, propylene glycol monoester, propylene glycol diester, butylene glycol monoester, butylene glycol diester, polyethylene glycol diester, and combinations thereof.

A method of preparing an injectable pharmaceutical composition, the method comprising:

• a) providing a mixture comprising:
• a biopharmaceutical agent;
• and
• a polyacrylamide-based copolymer in water;
• b) removing the water from the mixture to obtain particles comprising the biopharmaceutical agent and the polyacrylamide-based copolymer;
• and
• c) contacting a liquid carrier with the particles to form a suspension of the particles in the liquid carrier.