Composition for preventing or treating vascular diseases, containing hapln1

Abstract

The present invention relates to a composition for repairing vascular degeneration and vascular injuries and preventing or treating vascular diseases, containing hyaluronan and proteoglycan link protein 1 (HAPLN1) as an active ingredient. More specifically, provided is a pharmaceutical composition and a health functional food composition for preventing or treating vascular diseases, containing HAPLN1 as an active ingredient. HAPLN1 inhibits and alleviates, in blood vessel walls, damage to the elastin fiber layer and loss of transgelin, and effectively inhibits the phosphorylation of NF-κB or focal adhesion kinase (FAK) in vascular smooth muscle cells (VSMCs), and thus can be used for preventing, alleviating or treating vascular injuries and various diseases caused by aging or a high-fat diet.

Dependencies are inferred from the claim text.