Methods of treating traumatic brain injury and related neurological conditions

Abstract

Methods of treating or mitigating, in a subject, traumatic brain injury (TBI), post-traumatic stress disorder (PTSD), and symptoms and conditions characteristic thereof, such as decreased cerebral blood flow (CBF), ischemia/hypoxia, and sensory, locomotor, generalized anxiety disorder (GAD), anxiety-like behaviors, and affective and cognitive dysfunction, by administering at least one Nociceptin Opioid Peptide (NOP) receptor partial agonist or antagonist to the subject. In at least certain non-limiting embodiments, subjects with TBI, PTSD, or both TBI and PTSD may be treated with at least one NOP receptor partial agonist or antagonist shortly after any type of TBI, thereby preventing or mitigating disrupted blood flow to the brain and the rapid and sustained impairments that would otherwise ensue.

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