Compositions and Methods for Treating Persistent Postsurgical Pain
AssigneeCreative Bio-Peptides Inc.
InventorMichael RUFF
Life of this patent
Estimating the term…
Abstract
Disclosed herein are polypeptides, derivatives thereof, and salts thereof, as well as pharmaceutical compositions containing these, useful alone or in combination with other therapies for treating weight loss, weight gain, or to maintain a healthy body weight in a subject. Also disclose herein are the use of the peptides disclosed herein for treating stress, depression, anxiety, and pain catastrophizing. In some cases, the subject can be suffering from persistent postsurgical pain.
Claims36
A method of inducing weight gain in a subject in need thereof, inducing weight loss in a subject in need thereof, or inducing a healthy weight in a subject in need thereof, the method comprising:
- administering to the subject a therapeutically effective amount of a pharmaceutical composition to induce weight gain in the subject in need thereof, induce weight loss in the subject in need thereof, or to induce healthy weight in the subject in need thereof, wherein the pharmaceutical composition comprises:
- a polypeptide, a derivative thereof, or a salt thereof, wherein the polypeptide comprises at least five contiguous amino acids or derivatives thereof comprising the general formula:
- E-F-G-H-I, wherein:
- E is D-Ser, D-Thr, D-Asn, D-Glu, D-Arg, D-Ile, or D-Leu, or a derivative of any of these;
- F is D-Ser, D-Thr, D-Asp, or D-Asn, or a derivative of any of these;
- G is D-Thr, D-Ser, D-Asn, D-Arg, D-Gln, D-Lys, or D-Trp, or a derivative of any of these;
- H is D-Tyr, or a derivative thereof;
- and
- I is D-Thr, D-Ser, D-Arg, or Gly, or a derivative of any of these.
A method of administering a polypeptide to treat Persistent Postsurgical Pain (PPSP) in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a pharmaceutical composition to treat PPSP, wherein the pharmaceutical composition comprises:
- a polypeptide, a derivative thereof, or a salt thereof, wherein the polypeptide comprises at least five contiguous amino acids or derivatives thereof comprising the general formula:
- E-F-G-H-I, wherein:
- E is D-Ser, D-Thr, D-Asn, D-Glu, D-Arg, D-Ile, or D-Leu, or a derivative of any of these;
- F is D-Ser, D-Thr, D-Asp, or D-Asn, or a derivative of any of these;
- G is D-Thr, D-Ser, D-Asn, D-Arg, D-Gln, D-Lys, or D-Trp, or a derivative of any of these;
- H is D-Tyr, or a derivative thereof;
- and
- I is D-Thr, D-Ser, D-Arg, or Gly, or a derivative of any of these.
Dependencies are inferred from the claim text.