A water-soluble glass rumen bolus
AssigneeBimeda Animal Health Limited
InventorsDaniel Peter TIERNEY, Donal Thomas Martin TIERNEY
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Abstract
A water-soluble glass bolus article in a form suitable for oral administration to a ruminant animal, the article comprising carboxylate glass and an organic active agent. Metal carboxylates such as acetates, propanoates and butanoates can be melted to a glass and have a lower melting temperature than phosphate-based glass materials, allowing thermally sensitive active agents to be formulated into a glass bolus article. The carboxylate glass is formed from one or more metal carboxylates having a melting point of less than 300° C. in which the anion is selected from one or more acetates, propanoates, or a mixture of carboxylate anions. The metal may be selected from sodium, potassium, calcium and zinc.
Claims17
A water-soluble glass bolus article in a form suitable for oral administration to a ruminant animal, the article comprising:
- carboxylate glass;
- and
- an organic active agent.
A water-soluble glass bolus article according to any preceding claim comprising 1-20% organic active agent by weight.
A water-soluble glass bolus article according to any preceding claim in which the organic active agent is selected from a vitamin, antibiotic, and plant extract.
A water-soluble glass bolus article according to any preceding claim in which the plant extract is a seaweed extract enriched in bromoform.
A water-soluble glass bolus article according to any preceding claim in which the glass bolus article has a specific gravity of 1 to 7 g/cm3.
A water-soluble glass bolus article according to any preceding claim in which the glass bolus article has a specific gravity of 2 to 4 g/cm3.
A method of forming a water-soluble glass bolus article comprising the steps of:
- melting one or more metal carboxylates at a temperature of less than 300° ° C. to form a liquid carboxylate glass;
- allowing the liquid carboxylate to cool to provide a solid carboxylate glass;
- milling the solid carboxylate glass to provide carboxylate glass particles;
- mixing the carboxylate glass particles with an organic active agent;
- pressing the mixture to form a bolus article;
- and
- sintering the bolus article to form a sintered water-soluble glass bolus article.
Dependencies are inferred from the claim text.