Treatment and prevention of neuropathology associated with neurodegenerative diseases
AssigneeILiAD Biotechnologies, LLC
InventorsKeith Rubin, Steven Glazer, Marina Lynch, Kingston Mills
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Abstract
Administering a live, attenuated Bordetella pertussis-based vaccine to a subject at risk for developing a neurodegenerative disease featuring Aβ brain plaques can prevent or reduce the amount of Aβ brain plaques that would have developed in the subject without such treatment.
Claims13
A method for preventing or reducing β-amyloid plaque in the brain of a subject having or at risk for developing Alzheimer's disease, the method comprising the step of administering to the subject a vaccine comprising a pharmaceutically suitable excipient or carrier and a sufficient number of live, attenuated Bordetella pertussis bacteria to colonize the subject and induce a protective response in the subject that reduces the amount of β-amyloid plaque that would have formed or would have been present in the brain of the subject if the subject were not administered the composition.
Dependencies are inferred from the claim text.