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US 2024/0252549 A1Published application
Compositions and methods to transfect, test, and treat skin cells
AssigneeThe Regents of the University of Michigan
InventorsMichelle J. Kahlenberg, Mrinal K. Sarkar, Johann E. Gudjonsson
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Abstract
The present invention provides compositions and methods for enhancing transfection efficiency. In particular, the present invention provides compositions and methods that increase transfection efficiency of skin cells, including keratinocytes, which facilitates use of gene expression modifying technologies such as CRISPR-Cas technologies.
Claims20
A composition comprising:
- a) one or more JAK1 and/or JAK2 inhibitors;
- b) one or more transfection reagents;
- and
- c) one or more nucleic acid molecules.
1 more element
A method comprising:
- a) contacting a skin cell with a JAK1 and/or JAK2 inhibitor;
- and
- b) transfecting the skin cell with one or more nucleic acid molecules.
Dependencies are inferred from the claim text.