Cellular composition for treatment of diseases, disorders or conditions and method of use
OwnerYaacov GUYinventor
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Abstract
The present invention relates to a cellular composition, more particularly a composition comprising a serotonin receptor-expressing cells that have been exposed to a serotonin receptor agonist and consequently stimulated, for use in the treatment of a disease, disorder or condition; a method of use; and a method for preparing such a composition.
Claims21
1-32. (canceled)
A method of treatment of a disease, disorder or condition in a subject in need thereof said method comprising the steps of:
- (i) contacting a composition comprising serotonin (5-HT) receptor-expressing cells with a serotonin receptor agonist;
- or a prodrug of said serotonin receptor agonist in the presence of an enzyme capable of converting said prodrug to said serotonin receptor agonist, thereby stimulating said cells, wherein said cells are either autologous cells obtained from said subject or allogeneic cells obtained from a donor;
- and
- (ii) administering a therapeutically effective amount of the stimulated cells obtained in step (i) to said subject to thereby treat said disease, disorder or condition.
An in vitro method for stimulating serotonin receptor-expressing cells to be used either as a therapeutic product or in making a therapeutic product, said method comprising contacting said cells with (a) a serotonin receptor agonist;
- or (b) a prodrug of said serotonin receptor agonist in the presence of an enzyme capable of converting said prodrug to said serotonin receptor agonist.
Dependencies are inferred from the claim text.