Methods and compositions for pancreatic cancer evaluation and treatment
AssigneeBoard of Regents, The University of Texas System
InventorsRaghu KALLURI, Krishnan MAHADEVAN
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Abstract
Aspects of the present disclosure are directed to methods for treating a subject having pancreatic cancer. Certain aspects relate to treatment with cancer immunotherapy, including immune checkpoint blockade therapy. In some cases, a subject has been determined to have or to have had an inflammatory condition, such as pancreatitis. Further aspects relate to methods for identifying a subject as a candidate for an immune checkpoint blockade therapy.
Claims115
A method for treating a subject with pancreatic cancer, the method comprising providing an immunotherapy to the subject, wherein the subject has been determined to have or to have had pancreatitis.
A method for treating a subject with pancreatic cancer, the method comprising:
- (a) identifying the subject as having pancreatitis or as having previously had pancreatitis;
- and
- (b) providing an immunotherapy to the subject.
A method for treating a subject with pancreatic cancer, the method comprising determining whether the subject has or has previously had pancreatitis and:
- (a) providing an immunotherapy to the subject if the subject is determined to have or to have previously had pancreatitis;
- or
- (b) providing an alternative cancer therapy to the subject if the subject is determined to have never had pancreatitis, wherein the alternative cancer therapy does not comprise an immunotherapy.
A method for treating a subject with pancreatic cancer, the method comprising:
- (a) inducing pancreatitis in the subject;
- and
- (b) subsequent to (a), providing to the subject an immunotherapy.
A method for treating a subject with pancreatic cancer, the method comprising administering an effective amount of a dendritic cell vaccine and an immunotherapy to the subject.
A method for treating a subject for pancreatic cancer, the method comprising administering an immunotherapy to a subject determined to have tertiary lymphoid structures in pancreatic cancer tissue from the subject.
A method for treating a subject for pancreatic cancer, the method comprising:
- (a) detecting tertiary lymphoid structures in pancreatic tissue of the subject;
- and
- (b) administering an immunotherapy to the subject.
A method for treating a subject for pancreatic cancer, the method comprising:
- (a) inducing formation of tertiary lymphoid structures in pancreatic tissue of the subject;
- and
- (b) administering an immunotherapy to the subject.
A method for identifying subjects with pancreatic cancer as candidates for immune checkpoint blockade therapy, the method comprising:
- (a) determining whether each subject of a group of subjects with pancreatic cancer has or has previously had pancreatitis;
- and
- (b) identifying subjects from the group of subjects that have or have previously had pancreatitis as candidates for immune checkpoint blockade therapy.
Dependencies are inferred from the claim text.