Therapeutic agents and their use for treating chronic wounds
AssigneesBeth Israel Deaconess Medical Center, Inc., President and Fellows of Harvard College
InventorsAristidis Veves, George Theocharidis, Zhuqing Li, Ioannis Vlachos, David J. Mooney, Sangmin Lee
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Abstract
In certain aspects, the disclosure relates to devices and methods for treating wounds wherein an acetylcholinesterase inhibitor is delivered to a wound to promote wound healing. In further aspects, metrifonate can be delivered to the wound by time release from a wound dressing. In further aspects a sequence of wound dressings can be applied to the wound to treat different phases of wound healing.
Claims35
A wound dressing comprising:
- an alginate hydrogel having a therapeutic amount of an acetylcholinesterase inhibitor distributed therein for release onto an ulcerative wound during a delivery period.
12-16. (canceled)
22-28. (canceled)
A method of treating a diabetic ulcer wound in a subject, comprising:
- applying a wound dressing to the diabetic ulcer wound of the subject, the wound dressing comprising:
- a) a therapeutically effective amount of an acetylcholinesterase inhibitor;
- and
- b) an alginate hydrogel configured to release a therapeutic dose of the acetylcholinesterase inhibitor onto the wound for a delivery period.
40-44. (canceled)
48-54. (canceled)
Dependencies are inferred from the claim text.