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US 2024/0252501 A1Published application
METHOD OF TREATING PATIENTS COADMINISTERED A FACTOR Xa INHIBITOR AND VERAPAMIL
AssigneeMorgandane Scientific, LLC
InventorsSundar SRINIVASAN, Maulik PATEL, Christina CHOW WALLEN
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Abstract
The present disclosure in various embodiments teaches methods of treating patients in need of treatment with a Factor Xa inhibitor, and who are also concomitantly administered verapamil.
Claims20
A method of treating a patient in need of treatment with a Factor Xa inhibitor and a calcium channel blocker, comprising:
- (a) administering about 100 to about 480 mg verapamil daily to the patient;
- and
- (b) administering a dose of rivaroxaban to the patient which is less than the dose that would be recommended for that patient if the patient was not concomitantly administered verapamil;
- wherein after administering the rivaroxaban, the patient exhibits one or more of the following:
- a steady state rivaroxaban AUC of no more than about 3792 μg-hr/L;
- a steady state Cmax of no more than about 317 ng/mL;
- a risk of major bleeding of no more than about 4.5%;
- or
- a prothrombin time of 20-30 seconds.
6 more elements
Dependencies are inferred from the claim text.