Methods, compositions, and devices for drug / live cell microarrays
AssigneePathak Holdings LLC
InventorChandrashekhar P. Pathak
Life of this patent
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Abstract
This invention discloses methods and composition to form biodegradable polymer implant arrays in the live tissue. Artificial cavities are created in the live tissue by using laser ablation, oscillating needle, microneedle array and other methods. The cavities are then filled with biodegradable polymer solution. The solvent in the polymer solution is dissipated in the tissue to form a biodegradable polymer implant in artificial cavities. The cavities and implants formed are arranged to form of an array of implants. The biodegradable polymer in the cavity can also be loaded with drug to form biodegradable drug delivery array in the live tissue.
Claims32
An implantable microneedle array, comprising:
- a plurality of microneedles arranged in an array, wherein each microneedle includes a crosslinked body that is biodegradable and that has a tip and opposite base surface, wherein the crosslinked body is formed by polymerizing a biodegradable macromonomer that has at least two free radically polymerizable groups separated by at least one biodegradable block;
- and
- a backing member coupled to the base surface of each microneedle in the array.
A method of forming a microneedle array, comprising:
- providing a mold having a plurality of cavities shaped as microneedles arranged in an array;
- introducing a precursor as a neat liquid or solution into each cavity of the mold, wherein the precursor solution includes a free radical initiator and a macromonomer;
- exposing the precursor solution to a stimulus to initiate polymerization of the macromonomer to form a crosslinked body shaped as the microneedles, wherein each microneedle includes a crosslinked body that is biodegradable and that has a tip and opposite base surface;
- attaching a backing member to the base surface of each microneedle in the array;
- and
- withdrawing the microneedles from the mold, wherein the microneedles are arranged in the array and include the backing member coupled thereto.
Dependencies are inferred from the claim text.