Pulmonary biguanide formulations and delivery devices
AssigneeOnconox Inc.
InventorSitaram Velaga
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Abstract
Compositions for pulmonary delivery comprising a biguanide or a pharmaceutically acceptable salt thereof in a form suitable to be aerosolized for pulmonary delivery to a human subject, and methods of treating lung disease.
Claims26
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A pulmonary delivery system for delivery of a biguanide composition comprising a biguanide or a pharmaceutically acceptable salt thereof in a form suitable to be aerosolized for pulmonary delivery to a human subject and a vibrating mesh nebulizer, wherein at least 19% of the emitted dose of biguanide is contained in droplets or particles having aerodynamic particle sizes of 5 microns or less.
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The pulmonary delivery system of claim of 11, wherein between about 10 mg to about 100 mg of biguanide is emitted per minute.
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Dependencies are inferred from the claim text.