Fastening devices and related methods of use

A medical device, comprising:

• a fastener including at least two jaws, wherein the fastener is releasably coupled to an adapter;
• a handle including a wheel;
• a first cable coupled to a first portion of the wheel;
• a second cable coupled to a second portion of the wheel;
• and
• a third cable coupled to the second portion of the wheel;
• wherein rotation of the wheel in a first direction is configured to increase tension on the first cable to move the fastener distally;
• and
• wherein rotation of the wheel in a second direction is configured to increase tension on the second cable to open the jaws.

A medical device, comprising:

• a fastener including at least two jaws, wherein the fastener is releasably coupled to an adapter, and wherein the adapter is configured to be coupled to a distal end of a shaft;
• a handle including a wheel;
• a first cable coupled to the wheel;
• a second cable coupled to the wheel;
• and
• a third cable coupled to the wheel;
• wherein rotation of the wheel in a first direction is configured to (a) move the fastener distally relative to the shaft or move the adapter proximally relative to the shaft and to (b) close the jaws;
• and
• wherein rotation of the wheel in a second direction is configured to (a) move the fastener proximally relative to the shaft or move the adapter distally relative to the shaft and (b) to open the jaws.