Continuous analyte monitoring system with microneedle array
AssigneeBiolinq Incorporated
InventorsJared Rylan TANGNEY, Joshua Ray WINDMILLER
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Abstract
Described herein are variations of an analyte monitoring system, including an analyte monitoring device. For example, an analyte monitoring device may include an implantable microneedle array for use in measuring one or more analytes (e.g., glucose), such as in a continuous manner. The microneedle array may include, for example, at least one microneedle including a tapered distal portion having an insulated distal apex, and an electrode on a surface of the tapered distal portion located proximal to the insulated distal apex. At least some of the microneedles may be electrically isolated such that one or more electrodes is individually addressable.
Claims30
A microneedle array for use in sensing a first analyte and a second analyte, comprising:
- a first microneedle comprising a first working electrode and a first biorecognition element configured to react with the first analyte, wherein a distal tip of the first microneedle is insulated;
- and
- a second microneedle comprising a second working electrode and a second biorecognition element configured to react with the second analyte, wherein a distal tip of the second microneedle is insulated,
- wherein the first analyte and the second analyte are different.
A microneedle array for use in sensing a first analyte and a second analyte, comprising:
- a first solid microneedle comprising a first working electrode and a first biorecognition element configured to react with the first analyte, wherein a distal edge of the first working electrode is offset from a distal tip of the first solid microneedle;
- and
- a second solid microneedle comprising a second working electrode, the second working electrode comprising a second biorecognition element configured to react with the second analyte, wherein a distal edge of the second working electrode is offset from a distal tip of the second solid microneedle,
- wherein the first analyte and the second analyte are different.
A microneedle array for use in sensing glucose and lactate, comprising:
- a first microneedle comprising a first working electrode and a first biorecognition element configured to react with the glucose, the first working electrode comprising a first electrode material, the first biorecognition element being entrapped within a first biorecognition layer disposed on the first electrode material, wherein the first biorecognition layer comprises a conducting polymer, and wherein a distal tip of the first microneedle is insulated;
- and
- a second microneedle comprising a second working electrode and a second biorecognition element configured to react with the lactate, the second working electrode comprising a second electrode material, the second biorecognition element being entrapped within a second biorecognition layer disposed on the second electrode material, wherein the second biorecognition layer comprises a conducting polymer, and wherein a distal tip of the second microneedle is insulated.
A method for sensing a plurality of analytes via a microneedle array, comprising:
- providing a first microneedle comprising a first working electrode and a first biorecognition element configured to react with a first analyte, wherein a distal tip of the first microneedle is insulated;
- providing a second microneedle comprising a second working electrode and a second biorecognition element configured to react with a second analyte, wherein a distal tip of the second microneedle is insulated;
- providing a third microneedle comprising a counter electrode;
- providing a fourth microneedle comprising a reference electrode;
- applying a first bias potential between the first working electrode and the reference electrode;
- applying a second bias potential between the second working electrode and the reference electrode;
- measuring a first current value between the first working electrode and the counter electrode, the first current value being proportional to a concentration of the first analyte;
- and
- measuring a second current value between the second working electrode and the counter electrode, the second current value being proportional to a concentration of the second analyte, wherein a first redox reaction occurs between the first working electrode and the counter electrode,
- wherein a second redox reaction occurs between the second working electrode and the counter electrode.
Dependencies are inferred from the claim text.