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US 2024/0248012 A1Published application
Systems and methods for monitoring tissue sample processing
AssigneeVentana Medical Systems, Inc.
InventorsJefferson Curtis Taft, David Chafin, Michael Otter, Benjamin Stevens
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Abstract
A tissue sample that has been removed from a subject can be evaluated. A change in speed of the energy traveling through the sample is evaluated to monitor changes in the biological sample during processing. The monitoring can detect movement of fluid with the sample and cross-linking. A system for performing the method can include a transmitter that outputs the energy and a receiver configured to detect the transmitted energy.
Claims20
A processing system, comprising:
- an acoustic monitoring device that detects acoustic waves that have traveled through a tissue sample;
- and
- a computing device communicatively coupled to the acoustic monitoring device, the computing device is configured to evaluate a speed of the acoustic waves based on a time of flight and including instructions, when executed, for causing the processing system to
- monitor diffusion of a fixative through the tissue sample using the acoustic monitoring device;
- and
- performing a fixation process on the tissue sample after the fixative has diffused through at least a portion of the tissue sample.
3 more elements
A method of fixing a tissue sample comprising:
- (a) immersing the tissue sample in a fixative at a first temperature of less than 15° C., and permitting the fixative to diffuse into the tissue sample for a first time period to obtain a fixative-diffused tissue sample;
- and
- (b) passively or actively heating the fixative to a second temperature for a second time period to permit cross-linking.
Dependencies are inferred from the claim text.