Modulators of Complement Factor B

A compound comprising a modified oligonucleotide consisting of 20 linked nucleosides having a nucleobase sequence consisting of the sequence recited in SEQ ID NO:

• 440 or SEQ ID NO:
• 455, or consisting of 16 linked nucleosides having a nucleobase sequence consisting of the sequence recited in SEQ ID NO:
• 598, wherein the modified oligonucleotide comprises:
• a gap segment consisting of ten linked deoxynucleosides;
• a 5′ wing segment consisting of five linked nucleosides for SEQ ID NO:
• 440 and SEQ ID NO:
• 455, or three linked nucleosides for SEQ ID NO:
• 598;
• and
• a 3′ wing segment consisting of five linked nucleosides for SEQ ID NO:
• 440 and SEQ ID NO:
• 455, or three linked nucleosides for SEQ ID NO:
• 598;
• wherein the gap segment is positioned between the 5′ wing segment and the 3′ wing segment, wherein
• each nucleoside of each wing segment of SEQ ID NO:
• 440 and SEQ ID NO:
• 455 comprises a 2′—O-methoxyethyl sugar;
• wherein each internucleoside linkage is a phosphorothioate linkage and wherein each cytosine is a 5-methylcytosine;
• and
• for SEQ ID NO:
• 598, the 5′ wing segment comprises a 2′—O-methoxyethyl sugar, 2′—O-methoxyethyl sugar, and cEt sugar in the 5′ to 3′ direction;
• wherein the 3′ wing segment comprises a cEt sugar, cEt sugar, and 2′—O-methoxyethyl sugar in the 5′ to 3′ direction;
• wherein each internucleoside linkage is a phosphorothioate linkage;
• and wherein each cytosine is a 5-methylcytosine.