Compositions and methods for modifying dna

A DNA compound having the formula:

• wherein
• R1 is hydrogen, a deoxynucleotide, or a first DNA sequence comprising the 5′ of a DNA hairpin;
• R2 is hydrogen, a deoxynucleotide, or a second DNA sequence comprising the 3′ of the DNA hairpin;
• L1 and L2 are independently a bond, —O—, —S—, —NH—, —C(O)NH2, —NHC(O)—, —C(O)O—, —OC(O)—, —S(O)2NH2, —NHS(O)2—, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, substituted or unsubstituted cycloalkylene, substituted or unsubstituted heterocycloalkylene, substituted or unsubstituted arylene, or substituted or unsubstituted heteroarylene, a peptide linker, or a cleavable linker;
• R3 is a detectable moiety, a biomolecular moiety, a therapeutic moiety, hydrogen, halogen, —CX3.13, —CHX3.12, —CH2X3.1, —CN, —SOn1R3A, —SOv1NR3BR3C, —NHNR3BR3C, —ONR3BR3C, —NHC(O)NHNR3BR3C, —NHC(O)NR3BR3C, —N(O)m1, —NR3BR3C, —C(O)R3D, —C(O)OR3D, —C(O)NR3BR3C, —OR3A, —NR3BSO2R3A, —NR3BC(O)R3D, —NR3BC(O)OR3D, —NR3BOR3D, —OCX3.13, —OCHX3.12, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R3A, R3B, R3C and R3D are independently hydrogen, halogen, —CF3, —CCl3, —CBr3, —CI3, —CHCl2, —CHBr2, —CHF2, —CHI2, —CH2Cl, —CH2Br, —CH2F, —CH2I, —CN, —OH, —NH2, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2,
• —NHC(O)NHNH2, —NHC(O)NH2, —NHSO2H, —NHC(O)H, —NHC(O)—OH, —NHOH, —OCF3, —OCCl3, —OCBr3, —OCI3, —OCHF2, —OCHCl2, —OCHBr2,
• —OCHI2, —OCH2Cl, —OCH2Br, —OCH2I, —OCH2F, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R3B and R3C substituents bonded to the same nitrogen atom may optionally be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• and
• X3.1 is independently —Cl, —Br, —I or —F.