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US 2024/0247207 A1Published application
Maltoside-, lactobionamide-, monoglucoside-, branched diglucoside-, sulfobetaine-, sulfate- or aminooxide-based perfluorinated detergents and their use in membrane-proteins applications
AssigneesAvignon Université, Centre National De La Recherche Scientifique, Universite De Montpellier, Ecole Nationale Superieure De Chimie De Montpellier
InventorsGRÉGORY DURAND, MOHEDDINE WEHBIE
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Abstract
The present invention relates to new amphiphilic perfluorinated compounds and their use as a detergent for extracting membrane-proteins or synthesizing membrane-proteins in acellular system. It also relates to a method for extracting a membrane-protein from a biological sample using such compounds.
Claims16
1-16. (canceled)
A compound represented by the following formula (I):
- wherein:
- X is a polar moiety selected from a maltoside, a lactobionamide, a glucoside, a sulfobetaine, an aminoxide, a sulfate, and a branched diglucoside moiety;
- Y is a (C1-C12) aliphatic linker, optionally comprising one or more heteroatomic groups selected each independently from —O—, —NH—, —S—, —C(O)—, —NH—C(O)—, —C(O)—NH—, —C(O)—O—, —O—C(O)—, —NH—C(O)—O—, —O—C(O)—NH— and triazole;
- and
- Z is selected from a perfluorinated (C3-C12)cycloalkyl and a branched perfluorinated (C3-C12)alkyl.
2 more elements
Dependencies are inferred from the claim text.