Multi-functional conducting polymer coating on vascular access devices
AssigneeBecton, Dickinson and Company
InventorLeandro Forciniti
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Abstract
Provided are conductive films including a heparin modified polymer. The heparin modified polymer comprises heparin covalently bound to a beta-substituted monomer having a conjugated backbone that is co-polymerized to its non-functionalized pair. The heparin modified polymer on a conductive film can be manufactured by co-polymerizing a beta-substituted monomer with a non-functionalized monomer to form a polymer on a conductive film. The polymer is reacted with N,N′-Dicyclohexylcarbodiimide (DCC) and acetic acid to form an anhydride of the polymer on the conductive film. The anhydride is then reacted with heparin to form the heparin modified polymer on the conductive film. Medical devices having a coating comprising the conductive film are also described.
Claims20
A conductive film comprising a heparin modified polymer, the heparin modified polymer comprising heparin covalently bound to a beta-substituted monomer having a conjugated backbone that is co-polymerized to its non-functionalized pair.
A method of manufacturing a heparin modified polymer on a conductive film, the method comprising:
- co-polymerizing a beta-substituted monomer with a non-functionalized monomer to form a polymer on a conductive film;
- reacting the polymer with N,N′-Dicyclohexylcarbodiimide (DCC) and acetic acid to form an anhydride of the polymer on the conductive film;
- and
- reacting the anhydride with heparin to form the heparin modified polymer on the conductive film.
Dependencies are inferred from the claim text.