Macrocyclic lrrk2 kinase inhibitors

A compound of formula (I):

• wherein:
• R represents a hydrogen atom, a halogen atom or an alkyl group,
• Z1, Z2, Z3, each independently represent a carbon or a nitrogen atom, wherein the 6-membered cycle containing Z1, Z2 and 73 may have 0, 1 or 2 nitrogen atoms,
• —X— represents —O—, —S—, —S(O)—, S(O)2— or —N(Ra)—, wherein Ra represents a hydrogen atom or an alkyl group,
• —X2- represents —O—, —S—, —S(O), S(O)2— or —N(Ra)—, wherein Ra represents a hydrogen atom or an alkyl group,
• —X3- represents —O—, —S—, —S(O)—, S(O)2—, —N(Ra)— or a bond, wherein Ra represents a hydrogen atom or an alkyl group,
• +Y1- represents a bond or a linear or branched (C1-C3) alkanediyl group optionally substituted with one or more substituents, which may be identical or different, selected from a halogen atom, a polyhalogenoalkyl group, an alkoxy group, a hydroxy group, an amino group, an alkylamino group, a dialkylamino group and a cyano group,
• Y1- and —Y2-, which may be identical or different, each represent a linear or branched (C2-C6) alkanediyl group, a linear or branched (C2-C6) alkenediyl group, or a linear or branched (C3-C6) cycloalkanediyl group, which groups may be optionally substituted:
• by one or more halogen atoms,
• or by one substituent selected from a polyhalogenoalkyl group, an alkoxy group, a hydroxy group, an oxo group, an amino group, an alkylamino group, a dialkylamino group and a cyano group,
• wherein the carbon atom of the such defined —Y0-, —Y1- or —Y2- groups which is in an alpha position of a heteroatom —X1-, —X2- or —X3-, may not be substituted with an oxygen or a nitrogen heteroatom, unless it is an oxo group,
• —Y3- represents a bond, a linear or branched (C1-C6) alkanediyl group, a linear or branched (C2-C6) alkenediyl group, or a linear or branched (C3-C6) cycloalkanediyl group, which groups may be optionally substituted by one or more substituents, which may be identical or different, selected from a halogen atom, a polyhalogenoalkyl group, an alkoxy group, a hydroxy group, an amino group, an alkylamino group, a dialkylamino group and a cyano group,
• wherein the carbon atom of the such defined —Y3- group which is in an alpha position to a heteroatom —X3- or A1 when A1 represents a nitrogen atom, may not be substituted with an oxygen or a nitrogen heteroatom,
• A represents
• an aromatic or partially hydrogenated cyclic group of the formula (a):
• wherein
• A1, A4 each independently represent a carbon atom or a nitrogen atom,
• A2, A3, A5 each independently represent a carbon atom, an oxygen atom, a sulfur atom or a nitrogen atom,
• wherein, when A1 represents a nitrogen atom, it may not be linked to a heteroatom of the —Y0-X1-Y1-X2-Y2-X3-Y3- chain, and
• wherein * means that the bond is linked to Y3,
• or an aromatic or partially hydrogenated cyclic group of the formula (b):
• wherein
• A′1, A′2, A′3, A′4 each independently represent a carbon atom or a nitrogen atom,
• wherein * means that the bond is linked to Y3,
• and wherein
• the cyclic group A such defined may be optionally substituted by one or more substituents, which may be identical or different, selected from a halogen atom, an alkyl group, an alkoxy group, a hydroxy group, an oxo group, an alkoxyalkyl group, an alkoxyalkoxy group, a polyhalogenoalkyl group, a polyhalogenoalkoxy group, a heterocycloalkyl group, a heterocycloalkylalkyl group, an (alkoxyalkyl)(alkyl)amino group, an amino group, an alkylamino group, a dialkylamino group, a cycloalkyl group, a (heterocycloalkyl)(alkyl)amino group, a dialkylaminoalkyl group, a heterocycloalkylalkoxy group, a cyano group and a cyanoalkyl group,
• wherein the heterocycloalkyl and cycloalkyl group may be optionally substituted by one or more substituents selected from an alkyl group, a halogen atom, a polyhalogenoalkyl group, a polyhalogenoalkoxy group, an alkoxy group, an alkoxyalkyl group, a hydroxy group, a cyano group and an oxo group,
• its enantiomers, diastereoisomers, tautomers, racemic mixtures, hydrate, solvates, N-oxide, isotopes, deuterated derivatives and addition salts thereof with a pharmaceutically acceptable acid or base.