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US 2024/0246935 A1Published application
Aryl compounds and pharmaceutical compositions that modulate ikzf2
AssigneePlexium, Inc.
InventorsPengyu Yang, Simon Bailey
Life of this patent
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Abstract
Disclosed are compounds and salts thereof that bind to and modulate cereblon activity. In some embodiments, the binding and modulation of cereblon results in the degradation of IKAROS family zinc finger proteins (e.g., IKZF2). The compounds are of formula I:
Claims21
1-31. (canceled)
A compound selected from:
- or a pharmaceutically acceptable salt, solvate, stereoisomer, or tautomer thereof.
A pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound selected from:
- or a pharmaceutically acceptable salt, solvate, stereoisomer, or tautomer thereof.
Dependencies are inferred from the claim text.