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US 2024/0246929 A1Published application
Preparation method of l-nicotine
AssigneesHuanggang Zy Biotechnology Co., Ltd., Wuhan Rs Pharmaceuticals Co., Ltd., Wuhan Qr Pharmaceuticals Co., Ltd.
InventorsLitao SHEN, Yaoxiu LIU
Life of this patent
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Abstract
A preparation method for L-nicotine involves multiple steps. The resulting L-nicotine can have an optical purity of more than 99.9%, much higher than that of similar products in the current market. The total yield of synthesis reaches 50-60%.
Claims10
A preparation method for L-nicotine, having the following synthetic route:
- wherein the preparation method comprises the following steps:
- (1) subjecting a compound of formula I to a substitution reaction with N-vinylpyrrolidone, and performing decarboxylation to obtain a compound of formula II;
- (2) subjecting the compound of formula II to a cyclization reaction to obtain myosmine;
- and
- (3) subjecting myosmine to reduction and methylation to obtain L-nicotine;
- in the compound of formula I, R is selected from C1-C8 alkyl, phenyl, and benzyl.
3 more elements
A catalyst generated in situ from a ligand and a metal catalyst, wherein the metal catalyst is selected from Rh(COD)Cl2, Ir(COD)Cl2, Ru(COD)Cl2, PdCl(PPh3)3, PdCl2(PPh3)2, Ni(acac)2, NiCl2, and Ni(COD)2;
- the ligand is selected from the following structures:
Dependencies are inferred from the claim text.