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US 2024/0245772 A1Published application
Bi-specific chimeric antigen receptors and genetically engineered immune cells expressing such
AssigneeCelledit LLC
InventorBiliang Hu
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Abstract
A bi-specific chimeric antigen receptor (bi-specific CAR) comprising a single chain variable fragment (scFv) and a single variable domain (VHH) in the extracellular antigen binding domain, wherein the scFv and VHH bind tumor associated antigens. Also provided herein are genetically engineered immune cells expressing such bi-specific CAR and therapeutic uses of the genetically engineered immune cells.
Claims44
A bi-specific chimeric antigen receptor (CAR) polypeptide, comprising:
- a) a first antigen binding moiety,
- b) a second antigen binding moiety,
- c) a co-stimulatory signaling domain, and
- d) a cytoplasmic signaling domain,
- wherein the first antigen binding moiety is a single domain antibody variable fragment (VHH) and the second antigen binding moiety is a single chain variable fragment (scFv), and
- wherein the first antigen binding moiety binds a first tumor-associated antigen, and the second antigen binding moiety binds a second tumor-associated antigen, which optionally is different from the first tumor associated antigen.
3 more elements
A bi-specific chimeric antigen receptor (CAR) polypeptide, comprising:
- a) a first antigen binding moiety, which is a truncated fragment of APRIL that binds to BCMA;
- b) a second antigen binding moiety, which is a single domain antibody variable fragment (VHH) or a single chain variable fragment (scFv) that binds a tumor associated antigen,
- c) a co-stimulatory signaling domain, and
- d) a cytoplasmic signaling domain,
1 more element
Dependencies are inferred from the claim text.