Preservation of pancreatic islet grafts in the extrahepatic space
AssigneesThe Regents of the University of California, U.S. Govenment AS Represented By the Department of Veterans Affairs
InventorsCasey Ward, Qizhi TANG, Peter STOCK, Gaetano FALEO, Gopika NAIR, Matthias HEBROK, Wenhan CHANG, Thuy VO, Jeffrey A. BLUESTONE, Elenora DE KLERK
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Abstract
Provided herein, inter alia, are methods and compositions for treating diabetes mellitus comprising co-transplantation of an insulin-producing cell and a cell derived from a parathyroid gland (PTG), a CD34+ cell derived from a parathyroid gland, a CD34+ cell derived from a stem cell, or other progenitor cell-derived CD34+ cell.
Claims30
A method for promoting survival of an insulin-producing cell under hypoxic and/or nutrient poor conditions, comprising introducing the insulin-producing cell to the conditions in the presence of one or more factors selected from a proangiogenic factor, a parathyroid gland (PTG) hormone, and a combination thereof.
A method for promoting survival of an insulin-producing cell implanted in an extrahepatic space, comprising introducing to the extrahepatic space a transplant comprising the insulin-producing cell and one or more factors selected from a proangiogenic factor, a parathyroid gland (PTG) hormone, and a combination thereof.
A method for promoting engraftment of an insulin-producing cell in an individual, comprising administering to the individual a transplant comprising the insulin-producing cell and one or more factors selected from a proangiogenic factor, a parathyroid gland (PTG) hormone, and a combination thereof.
A method for treating diabetes mellitus in an individual, comprising administering to the individual a transplant comprising an insulin-producing cell and one or more factors selected from a proangiogenic factor, a parathyroid gland (PTG) hormone, and a combination thereof.
Dependencies are inferred from the claim text.