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US 2024/0245658 A1Published application
Taar1 and serotonin modulators, and pharmaceutical compositions, and methods of use thereof
AssigneeSunovion Pharmaceuticals Inc.
InventorsKevin Julian Hodgetts, Linghong Xie
Life of this patent
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Abstract
Provided herein is a compound of Formula (I): or a pharmaceutically acceptable salt thereof, wherein values for the variables (e.g., R1, R2, X1, X2, Y1, Y2, Y3, Y4, Y5, Y6, Y7, and Y8) are as disclosed herein. Also provided herein are pharmaceutical compositions comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and methods of using the compounds, pharmaceutically acceptable salts thereof and pharmaceutical compositions of the foregoing, e.g., to treat a neurological or psychiatric disease or disorder.
Claims65
A compound of Formula I
- or a pharmaceutically acceptable salt thereof, wherein:
- one of X1 and X2 is O, and the other is independently C(R3)2 or O;
- each R3 is independently H, (C1-C4)alkyl, (C2-C4)alkenyl, or (C2-C4)alkynyl;
- Y1, Y2, Y3, Y4, Y5, Y6, Y7, and Y8 are each independently C(R4) or N, and no more than one of Y1, Y2, Y3, Y4, Y5, Y6, Y7, and Y8 is N;
- each R4 is independently H, halogen, —CN, (C1-C4)alkyl, (C2-C4)alkenyl, (C2-C4)alkynyl, (C1-C4)haloalkyl, (C1-C4)alkoxy, or (C1-C4)haloalkoxy;
- and
- R1 and R2 are each independently H, (C1-C4)alkyl, or (C2-C4)alkenyl.
4 more elements
Dependencies are inferred from the claim text.