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US 2024/0240207 A1Published application
Increasing Specificity for RNA-Guided Genome Editing
AssigneeThe General Hospital Corporation
InventorsJ. Keith Joung, James Angstman, Shengdar Tsai
Life of this patent
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Abstract
Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems.
Claims22
1-30. (canceled)
A tracrRNA comprising one or more deoxyribonucleotides.
A composition comprising:
- a tracrRNA;
- a crRNA;
- and
- a S. pyogenes Cas9 protein or variant thereof,
- wherein the tracrRNA and/or the crRNA comprise a deoxyribonucleic acid.
2 more elements
Dependencies are inferred from the claim text.