Compositions and methods for treating osteoarthritis using a cd14 inhibitor
OwnerCarla R. Scanzello, Timothy Griffininventors
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Abstract
Disclosed herein are methods of treating or preventing the development of osteoarthritis after a joint injury by administering a CD14 inhibitor capable of neutralizing or blocking CD14, inhibiting CD14 function, inhibiting CD14 production, or a combination thereof. Also disclosed herein are methods of reducing or ameliorating one or more symptoms of osteoarthritis, reducing inflammation, reducing cartilage degradation, or treating or preventing subchondral bone sclerosis in a subject.
Claims20
A method of treating osteoarthritis or preventing the development of osteoarthritis after a joint injury in a subject, the method comprising:
- administering to the subject in need thereof, a therapeutically effective amount of a CD14 inhibitor, wherein the therapeutically effective amount of the CD14 inhibitor neutralizes or blocks CD14, inhibits CD14 function, inhibits CD14 production, or a combination thereof, thereby treating osteoarthritis or preventing the development of osteoarthritis after a joint injury in the subject.
(canceled)
A method of reducing cartilage degradation in a subject, the method comprising:
- administering to the subject, a therapeutically effective amount of a CD14 inhibitor, wherein the therapeutically effective amount of the CD14 inhibitor neutralizes or blocks CD14, inhibits CD14 function, inhibits CD14 production, or a combination thereof, thereby reducing cartilage degradation in the subject.
A method of treating or preventing subchondral bone sclerosis in a subject, the method comprising:
- administering to the subject, a therapeutically effective amount of a CD14 inhibitor, wherein the therapeutically effective amount of the CD14 inhibitor neutralizes or blocks CD14, inhibits CD14 function, inhibits CD14 production, or a combination thereof, thereby treating or preventing subchondral bone sclerosis in the subject.
Dependencies are inferred from the claim text.