Immunogenic composition
OwnerMichael GOOD, Hanan AL-NAZAL +1inventors
InventorsMichael GOOD, Hanan AL-NAZAL, Danielle STANISIC
Life of this patent
Estimating the term…
Abstract
The present disclosure provides immunogenic compositions and methods of inducing an immune response and/or preventing, treating or ameliorating an infection, disease or condition associated with an erythrocytic organism in a first mammal, wherein the erythrocytes are from a second mammal of a species different from the first mammal.
Claims31
An immunogenic composition for administration to a first mammal, said composition comprising erythrocytes and an erythrocytic organism, wherein the erythrocytes are from a second mammal of a species different from the first mammal.
The immunogenic composition of any one of the preceding claims, which does not comprise or is substantially free of an adjuvant.
The immunogenic composition of any one of the preceding claims, wherein the erythrocytes are contained in or otherwise associated with a particle.
The immunogenic composition of any one of the preceding claims, wherein the erythrocytes are contained in or otherwise associated with a liposome.
The immunogenic composition of any one of the preceding claims, further comprising a cell targeting ligand.
The immunogenic composition of any one of the preceding claims, wherein the erythrocytic organism has been chemically attenuated or inactivated.
The immunogenic composition of any one of the preceding claims, wherein the erythrocytes are intact.
The immunogenic composition of any one of the preceding claims, wherein the first mammal is a non-human animal.
The immunogenic composition of any one of the preceding claims, wherein the second mammal is human.
The immunogenic composition of any one of the preceding claims, wherein the erythrocytic organism is an intra-erythrocytic organism or an intra-erythrocytic parasite.
The immunogenic composition of any one of the preceding claims, wherein the erythrocytic organism is selected from the group consisting of a Babesia sp., an Anaplasma sp., an Ehrlichia sp., a Trypanosoma sp., a Theileria sp., a Hepatozoon sp., a Mycoplasma sp., a Bartonella sp. and any combination thereof.
The immunogenic composition of any one of the preceding claims, wherein the immunogenic composition provides heterologous protection against an infection, disease or condition associated with one or more other isolates, strains and/or species of the erythrocytic organism.
The immunogenic composition of any one of the preceding claims, wherein the immunogenic composition is for use in a method of:
- (a) eliciting an immune response in the first mammal;
- and/or
- (b) preventing, treating or ameliorating an infection, disease or condition associated with the erythrocytic organism in the first mammal.
Dependencies are inferred from the claim text.