Isolated or artificial nucleotide sequences for use in neurodegenerative diseases
AssigneeUniversidade Do Algarve
InventorsClévio David RODRIGUES NÓBREGA, Rebekah COVACO KOPPENOL, Adriana Isabel DO VALE MARCELO, André Filipe VIEIRA DA CONCEIÇÃO
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Abstract
The present disclosure relates to an isolated or artificial nucleotide sequence encoding the GTPase-activating protein-binding protein 1 (G3BP1), for use in medicine, preferably in the treatment of polyglutamine diseases. Furthermore, the present invention is also related to a vector comprising such sequence, a host cell comprising such vector, a protein G3BP1, or a composition thereof, for use for use in medicine, preferably in the treatment of polyglutamine diseases.
Claims20
1-20. (canceled)
A method of treating a nervous system disease in a subject, the method comprising administering to the subject an isolated or artificial nucleotide encoding the protein G3BP1, wherein the nucleotide comprises a sequence at least 95% identical to the sequence selected from the group consisting of:
- SEQ ID NO:1;
- SEQ ID NO:2;
- SEQ ID NO:3, SEQ ID NO:4;
- SEQ ID NO:5;
- SEQ ID NO:6;
- SEQ ID NO:7 and mixtures thereof.
A method of treating a nervous system disease in a subject, the method comprising administering to the subject a protein encoded by an isolated or artificial nucleotide, wherein the nucleotide comprises a sequence at least 95% identical to the sequence selected from the group consisting of:
- SEQ ID NO:1;
- SEQ ID NO:2;
- SEQ ID NO:3, SEQ ID NO:4;
- SEQ ID NO:5;
- SEQ ID NO:6;
- SEQ ID NO:7 and mixtures thereof.
Dependencies are inferred from the claim text.