Materials and methods for extracellular vesicle-associated diseases
AssigneeThe Brigham and Women's Hospital, Inc.
InventorsShinsuke ITO, Elena AIKAWA, Masanori AIKAWA
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Abstract
Sortilin is a sorting receptor that directs target proteins to the secretary or endocytic compartments of cells that is found in both extracellular vesicles and cells. Provided herein are methods and compositions for decreasing or inhibiting trafficking of sortilin to an extracellular vesicle, for example by inhibiting the formation of intermolecular sortilin dimers.
Claims17
A method for inhibiting or reducing trafficking of sortilin to an extracellular vesicle (EV) from a cell, the method comprising inhibiting covalent intermolecular dimerization of sortilin in the cell.
17-38. (canceled)
Dependencies are inferred from the claim text.