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US 2024/0229088 A1Published application
Polyamine analog producing yeasts
AssigneeChrysea Limited
InventorsJiufu Qin, Jens Nielsen
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Abstract
The invention relates to production of polyamine analogs in yeast cells that are capable of producing at least one polyamine. The yeast cells also comprise a 4-coumarate:CoA ligase encoding gene, at least one polyamine N-acyltransferase gene and at least one polyamine synthase encoding gene but lacks a polyamine oxidase encoding gene or comprises a disrupted polyamine oxidase encoding gene. The yeast cells are capable of producing mono- and/or multi-substituted N-acylated polyamines.
Claims21
A yeast cell capable of producing at least one polyamine analog, wherein
- the yeast cell is capable of producing at least one polyamine;
- the yeast cell comprises a 4-coumarate:
- CoA ligase encoding gene;
- the yeast cell comprises at least one polyamine N-acyltransferase gene;
- the yeast cell comprises at least one polyamine synthase encoding gene;
- and
- the yeast cell lacks a polyamine oxidase encoding gene or comprises a disrupted polyamine oxidase encoding gene.
4 more elements
Dependencies are inferred from the claim text.