SIRNA TARGETING 17Beta-HYDROXYSTEROID DEHYDROGENASE TYPE 13 AND SIRNA CONJUGATE

An siRNA, comprising a sense strand and an antisense strand forming a double-stranded region, wherein:

• the sense strand comprises at least 15 contiguous nucleotides and differs from any one of nucleotide sequences of SEQ ID NOs:
• 24, 4, 6, 11, 3, 5, 7, 8, 9, 10, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, and 23 by no more than 3 nucleotides;
• the antisense strand comprises at least 15 contiguous nucleotides and differs from any one of nucleotide sequences of SEQ ID NOs:
• 46, 26, 28, 33, 25, 27, 29, 30, 31, 32, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, and 45 by no more than 3 nucleotides.