DELIVERY OF BIOMOLECULES TO PBMCs TO MODIFY AN IMMUNE RESPONSE
AssigneeSQZ Biotechnologies Company
InventorsArmon R. SHAREI, Howard BERNSTEIN, Scott LOUGHHEAD, Matthew BOOTY, Katarina BLAGOVIC, Kelan HLAVATY, Defne YARAR, Emrah Ilker OZAY, Carolyne Kelly SMITH
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Abstract
The present application provides peripheral blood mononuclear cells comprising an antigen, methods of manufacturing such PBMCs, and methods of using such PBMCs, such as for modulating an immune response in an individual. In some embodiments, the PBMCs are conditioned by incubating the PBMC in the presence of an adjuvant.
Claims34
A plurality of modified PBMCs comprising an antigen, wherein the antigen is exogenous to the modified PBMCs.
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A method for stimulating an immune response in an individual in need thereof, comprising:
- a) incubating a plurality of PBMCs comprising an antigen with a conditioning agent for a sufficient time for the plurality of PBMCs to condition, thereby generating a conditioned plurality of PBMCs comprising the antigen;
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- b) administering the conditioned plurality of PBMCs comprising the antigen to the individual.
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A method of producing a conditioned plurality of PBMCs, the method comprising incubating a plurality of PBMCs with a conditioning agent for a sufficient time for the plurality of PBMCs to condition, thereby generating the conditioned plurality of PBMCs.
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Dependencies are inferred from the claim text.