Sirtuin modulating compounds and applications thereof

A sirtuin activating compound of Formula II and/or a salt thereof:

• wherein Ar1 is aryl or heteroaryl, R1-R6 are independently selected from the group consisting of hydrogen, alkyl, alkenyl, heteroalkyl, cycloalkyl, heterocycloalkyl, —C(O)R7, alkoxy, halo, nitryl (—NO2), and hydroxy, wherein the Ar1, alkyl, alkenyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl are optionally substituted with one or more substituents selected from the group consisting of (C1-C10)-alkyl, (C1-C10)-alkenyl, alkoxy, halo, amine, -alkoxy-amide, and hydroxy;
• and wherein R7 is selected from the group consisting of alkyl, alkenyl, and NR8R9, wherein R8 and R9 are independently selected from the group consisting of hydrogen, alkyl, and cycloalkyl;
• and wherein m and n are integers each having a value independently selected from 0 to 10.

12-13. (canceled)