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US 2024/0226243 A9Published application
Cholix toxin-derived fusion molecules for oral delivery of biologically active cargo
AssigneeApplied Molecular Transport Inc.
InventorsRandall J. Mrsny, Tahir Mahmood
Life of this patent
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Abstract
The present disclosure relates to pharmaceutical compositions comprising a non-naturally occurring fusion molecule and one or more pharmaceutically acceptable carriers, formulated for oral delivery to a subject, and designed to provide for improved, effective therapies for treatment of, e.g., inflammatory diseases, autoimmune diseases, cancer, metabolic disorders, and growth deficiency disorders.
Claims19
-29. (canceled)
A non-naturally occurring fusion molecule comprising (i) a variant of a Cholix polypeptide set forth in SEQ ID NO:
- 1, wherein the variant of the Cholix polypeptide consists of domain Ia, domain II, and a sequence of domain Ib, wherein the Cholix polypeptide is truncated at its C-terminus at an amino acid residue within domain Ib, coupled to (ii) an interleukin-10.
Dependencies are inferred from the claim text.