Amplitude modulated high-frequency stimulation to elicit stochastic neural spiking activity
AssigneesUniversity of Pittsburgh—Of the Commonwealth System of Higher Education, The Regents of the University of Michigan
InventorsBeatrice Barra, Lee Erik Bartholomew Fisher, Marco Capogrosso, Ehsan Mirzakhalili, Scott Lempka
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Abstract
Methods are disclosed for stimulating asynchronous and stochastic neural activity in a subject in need thereof. In some embodiments, the methods are used to provide asynchronous and stochastic neural activity in a limb of a subject with an amputation of the limb, for example, in a method of controlling the prosthetic limb of the subject.
Claims20
A method for stimulating asynchronous and stochastic neural activity in a subject, comprising:
- stimulating neurons in the subject by applying, with one or more electrodes of a neurostimulator implanted in the subject, an amplitude-modulated high-frequency (AM-HF) sinusoidal current (I) according to:
- I
- =
- I
- a
-
- sin
-
- (
- 2
-
- π
-
- f
- c
-
- t
- )
- +
- I
- b
-
- sin
-
- (
- 2
-
- π
-
- (
- f
- c
- +
- f
- b
- )
-
- t
- )
- (
- 1
- )
- wherein Ia and Ib are current values so that the maximum current amplitude is (Ia+Ib) and the minimum current amplitude value is ∥Ib−Ia∥, fc is about 800 Hz to about 20 kHz, fb is about 1 Hz to about 500 Hz, and t is time.
A method for providing asynchronous and stochastic neural activity in a limb of a subject with an amputation of the limb, comprising:
- providing a therapeutically effective amount of stimulation to peripheral neurons that innervate the limb of the subject and/or dorsal rootlets, or lateral spinal cord adjacent to the dorsal rootlets, of one or more sensory neurons that innervate the limb of the subject, wherein:
- the stimulation is provided with one or more electrodes of a neurostimulator that are implanted at the peripheral neurons that innervate the limb of the subject and/or dorsal rootlets or the lateral spinal cord adjacent to the dorsal rootlets of the one or more sensory neurons innervating the limb of the subject;
- the one or more electrodes are activated to provide the stimulation in response to activation of a sensor detecting movement and/or position of the limb or movement and/or position of a physical or virtual prosthesis of the limb;
- and
- wherein the stimulation is amplitude-modulated high-frequency (AM-HF) sinusoidal current (I) according to:
- I
- =
- I
- a
-
- sin
-
- (
- 2
-
- π
-
- f
- c
-
- t
- )
- +
- I
- b
-
- sin
-
- (
- 2
-
- π
-
- (
- f
- c
- +
- f
- b
- )
-
- t
- )
- (
- 1
- )
- wherein Ia and Ib are current values so that the maximum current amplitude is (Ia+Ib) and the minimum current amplitude value is ∥Ib−Ia∥, fc is about 800 Hz to about 20 kHz, fb is about 1 Hz to about 500 Hz, and t is time.
A method for control of a prosthetic limb of a subject, comprising:
- providing a therapeutically effective amount of stimulation to peripheral neurons that innervate the limb of the subject and/or dorsal rootlets, or lateral spinal cord adjacent to the dorsal rootlets, of sensory neurons innervating an amputated limb of the subject, wherein the subject uses a prosthesis of the amputated limb;
- and wherein:
- the stimulation is provided with one or more electrodes of a neurostimulator that are implanted at peripheral neurons that innervate the limb of the subject and/or the dorsal rootlets or the lateral spinal cord adjacent to the dorsal rootlets of the sensory neurons innervating the amputated limb;
- the one or more electrodes are activated to provide the stimulation in response to activation of a sensor detecting movement and/or position of a stump of the limb or the prosthesis or in response to movement and/or position of a virtual prosthesis of the limb;
- wherein the stimulation is amplitude-modulated high-frequency (AM-HF) sinusoidal current (I) according to:
- I
- =
- I
- a
-
- sin
-
- (
- 2
-
- π
-
- f
- c
-
- t
- )
- +
- I
- b
-
- sin
-
- (
- 2
-
- π
-
- (
- f
- c
- +
- f
- b
- )
-
- t
- )
- (
- 1
- )
- wherein Ia and Ib are current values so that the maximum current amplitude is (Ia+Ib) and the minimum current amplitude value is ∥Ib−Ia∥, fc is about 800 Hz to about 20 kHz, fb is about 1 Hz to about 500 Hz, and t is time;
- and
- and wherein the stimulation controls the prosthesis of the limb by the subject.
Dependencies are inferred from the claim text.