Synthesis of a cyclic peptide
AssigneeJanssen Pharmaceutica NV
InventorsPius Bruno Baur, Edward Cleator, Gildas Deniau, Frank Eisele, Oliver Flögel, Anja Huste, Marcel Roman Kehl, Markus Löweneck, Rolando Ravelo Silva, Raffael Vorberg
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Abstract
Processes for performing peptide synthesis, particularly for cyclic peptide synthesis are generally described. Reaction intermediates of the peptide synthesis are also described.
Claims58
A process for preparing a monocyclic peptide or a salt thereof, comprising coupling a monocyclic peptide fragment with a linear chain peptide fragment,
- wherein the monocyclic peptide fragment is a peptide containing between 4 and 11 amino acid residues;
- wherein the monocyclic peptide fragment comprises a ring containing between 4 and 8 amino acid residues;
- wherein the linear chain peptide fragment is a peptide containing between 4 and 10 amino acid residues;
- and wherein an amide bond is formed between the monocyclic peptide fragment and the linear chain peptide fragment.
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Dependencies are inferred from the claim text.