Compositions for chemical synthesis of peptides
AssigneeSederma
InventorCole Seifert
Life of this patent
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Abstract
The disclosure relates to compositions that can serve as anchors for the chemical synthesis of peptides. Anchor molecules can include GAP constituents, linker constituents, amino acid constituents, and/or stopper constituents. Anchor molecules can also include anchor peptides, wherein an anchor peptide can be removably coupled with an amino acid of a given sequence and act as a GAP anchor by achieving solubility control over the target peptide as it is synthesized via the addition of one or more other amino acids: the anchor peptide can then be removed from the target peptide. A novel method of peptide synthesis that utilizes novel anchor molecules and/or anchor peptides is also presented.
Claims20
A chemical composition comprising a GAP constituent, wherein the GAP constituent is selected from the group consisting of:
- wherein:
- R4 is selected from the group consisting of:
- H, methyl, ethyl, propyl, isopropyl, benzyl, isobutyl, sec-butyl, and tert-butyl;
- R5 is selected from the group consisting of:
- H, methyl, ethyl, propyl, isopropyl, benzyl, isobutyl, sec-butyl, and tert-butyl;
- R6 is selected from the group consisting of:
- —C(O)—, S, O, NH, NMe, Net, NBn, NPh, and —(CH2)p1—, wherein “p1” is an integer selected from the range of 0 up to and including 30;
- R7 is selected from the group consisting of:
- —C(O)—, S, O, NH, NMe, Net, NBn, NPh, and —(CH2)p2—, wherein “p2” is an integer selected from the range of 0 up to and including 30;
- R8 is selected from the group consisting of:
- —C(O)—, S, O, NH, NMe, Net, NBn, NPh, and —(CH2)p3—, wherein “p3” is an integer selected from the range of 0 up to and including 30;
- R9 is selected from the group consisting of:
- —C(O)—, S, O, NH, NMe, Net, NBn, NPh, and —(CH2)p4—, wherein “p4” is an integer selected from the range of 0 up to and including 30;
- R10 is selected from the group consisting of:
- —C(O)—, —(CH2)m—, and NH, wherein “m” is an integer selected from the range of 0 up to and including 30;
- “j” is an integer selected from the range of 0 up to and including 30;
- and
- “k” is an integer selected from the range of 0 up to and including 30.
A method of solution-phase peptide synthesis, the method comprising the steps of:
- attaching a first peptide to a first amino acid, wherein the first peptide is an anchor peptide;
- coupling one or more additional amino acids to the first amino acid to form a second peptide;
- and
- removing the first peptide from the second peptide.
A method of peptide synthesis, comprising the steps of:
- coupling an anchor to a first amino acid;
- and
- coupling a second amino acid with the first amino acid,
- wherein the anchor includes a compound selected from the group consisting of:
Dependencies are inferred from the claim text.