Chimeric antigen receptors to sialyl-tn glycan antigen
OwnerVered PADLER-KARAVANI, Ron AMON +5inventors
InventorsVered PADLER-KARAVANI, Ron AMON, Lihi NINIOMANY, Moran RAWET SLOBODKIN, Anat GLOBERSON LEVIN, Tova WAKS, Zelig ESHHAR
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Abstract
The present invention discloses chimeric antigen receptors that specifically recognize and bind to Sialyl Tn carbohydrate antigen with high specificity and selectivity. The invention further provides lymphocytic cells, such as T cells, comprising said CARs, compositions comprising said cells or CARs as well as uses thereof.
Claims21
1-41. (canceled)
A chimeric antigen receptor (CAR) comprising an antigen-binding domain that binds specifically to Sialyl Tn glycan (STn), wherein the antigen-binding domain comprises three complementarity determining regions (CDRs) of a heavy-chain variable domain (VH) having an amino acid sequence as set forth in SEQ ID NO:
- 1 and three CDRs of a light-chain variable domain (VL) having an amino acid sequence as set forth in SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.