Synthetic tissue barriers and uses thereof
AssigneesMassachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.
InventorsCarlo Giovanni Traverso, Ameya R. Kirtane, Junwei Li, Thomas Wang, James Byrne, Alexis Jones
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Abstract
The present disclosure provides compositions, methods, and kits that enable the in situ growth of polymers on or within a subject. In some aspects, the tissue-active monomers, including monomers comprising macromolecules, provide a broad set of material choices for synthetic tissue barriers. In additional aspects, the compositions, methods, and kits are useful for treating or preventing a disease or disorder.
Claims25
1-165. (canceled)
A solid dosage form comprising an active pharmaceutical agent, a monomer, and an oxygen source, wherein:
- the monomer comprises dopamine and a macromolecule, wherein the macromolecule comprises alginate, hyaluronic acid, polyacrylic acid, polyethylene glycol, chondroitin sulfate, chitosan, or a combination thereof;
- and
- when administered to a subject, the oxygen source contacts a catalyst in a tissue of the subject, and release of oxygen from the oxygen source polymerizes the monomer on the tissue;
- and
- the active pharmaceutical agent is retained or encapsulated in the polymer.
Dependencies are inferred from the claim text.