Composition for preventing or treating chronic kidney disease, comprising compound that induces expression of anti-aging gene klotho
AssigneeKlotho Sciences
InventorDong Ju JUNG
Life of this patent
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Abstract
The present invention relates to a composition for the prevention or treatment of chronic kidney disease (CKD), comprising compounds that induce the expression of the anti-aging gene klotho. The compounds represented by Chemical Formula 1 according to the invention are highly effective in enhancing the expression of the Klotho gene, a gene associated with aging, and thus can be useful for a pharmaceutical composition or a food composition for the prevention, amelioration or treatment of CKD.
Claims12
A method for preventing or treating chronic kidney disease, the method comprising administering a pharmaceutical composition comprising a compound represented by the following Chemical Formula 1 or a pharmaceutically acceptable salt thereof to a subject in need thereof:
- wherein,
- L1 is a single bond or
- R1 and R2 are each —H, —OH, a C1-10 straight or branched alkyl, or a C6-8 arylamide, wherein the aryl of the arylamide is optionally substituted with one or more of a halogen, —NO2 and a C1-10 straight or branched alkyl halide;
- R1 and R2 optionally form a C6-8 aryl with a carbon atom to which they are linked;
- and
- R3, R4, R5, R6 and R7 are each -H, a halogen, —NO2 or a C1-10 straight or branched alkyl).
A health functional food composition for preventing or improving chronic kidney disease, comprising a compound represented by Chemical Formula 1 or a pharmaceutically acceptable salt thereof:
- wherein,
- L1 is a single bond or
- R1 and R2 are each —H, —OH, a C1-10 straight or branched alkyl, or a C6-8 arylamide, wherein the aryl of the arylamide is optionally substituted with one or more of a halogen, —NO2 and a C1-10 straight or branched alkyl halide;
- R1 and R2 optionally form a C6-8 aryl with a carbon atom to which they are linked;
- and
- R3, R4, R5, R6 and R7 are each —H, a halogen, —NO2 or a C1-10 straight or branched alkyl).
A food composition for preventing or improving chronic kidney disease, comprising a compound represented by Chemical Formula 1 or a pharmaceutically acceptable salt thereof:
- wherein,
- L1 is a single bond or
- R1 and R2 are each —H, —OH, a C1-10 straight or branched alkyl, or a C6-8 arylamide, wherein the aryl of the arylamide is optionally substituted with one or more of a halogen, —NO2 and a C1-10 straight or branched alkyl halide;
- R1 and R2 optionally form a C6-8 aryl with a carbon atom to which they are linked;
- and
- R3, R4, R5, R6 and R7 are each —H, a halogen, —NO2 or a C1-10 straight or branched alkyl).
12-13. (canceled)
Dependencies are inferred from the claim text.