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US 2024/0215910 A1Published application
A method for evaluating the pro-or anti convulsive properties of test compounds
OwnerKaren Ka-Yen TSE, Royston Anthony GRAYinventors
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Abstract
The present invention relates to a method of evaluating the pro- or anti convulsive properties of test compounds that is both streamlined and is capable of providing a clear indication for the selection of candidate compounds during preclinical assessment.
Claims11
A method of assessing the pro- or anti-convulsant properties of a test compound comprising the following steps:
- a. dosing a number of animals with one of either a vehicle, the test compound or a positive control compound;
- b. determining if the animals produce a tonic hind limb extensor convulsion at a defined period of time post-dose from a single electroshock at a defined current;
- c. decreasing or increasing the defined current if the preceding animal did or did not produce tonic hind limb extensor convulsion, respectively and
- d. collecting CC50 values for the treated animals;
- characterized in that the number of animals used is at least 6.
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Dependencies are inferred from the claim text.