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US 2024/0210393 A1Published application
Detection and treatment of autoimmune disorders
AssigneeSeattle Children's Hospital
InventorsNeelufar Mozaffarian, Anne M. Stevens
Life of this patent
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Abstract
Disclosed herein are methods of treatment of autoimmune diseases such as systemic lupus erythematosus (SLE) as well as clinical assays for detection of autoimmune disease activity in patients utilizing a PD1 ligand.
Claims16
-39. (canceled)
A method of distinguishing between an active autoimmune disease and an autoimmune disease in remission in a human subject comprising:
- determining the amount of circulating PD-L1 in a blood sample obtained from the human subject by contacting the blood sample with a detectably labeled antibody specific for PD-L1;
- wherein a circulating PD-L1 amount that is lower than a control value is indicative of active autoimmune disease and a circulating PD-L1 amount that is about equal to the control value is indicative of remission.
Dependencies are inferred from the claim text.