Proline dehydrogenase 2 (prodh2) irna compositions and methods of use thereof

A double stranded ribonucleic acid (dsRNA) agent for inhibiting expression of proline dehydrogenase 2 (PRODH2) in a cell,

• a) wherein the dsRNA agent comprises a sense strand and an antisense strand forming a double stranded region, wherein the sense strand comprises at least 15 contiguous nucleotides differing by no more than 3 nucleotides from any one of the nucleotide sequence of SEQ ID NO:1, and said antisense strand comprises at least 15 contiguous nucleotides differing by no more than 3 nucleotides from any one of the nucleotide sequence of SEQ ID NO:
• 2;
• b) wherein the dsRNA agent comprises a sense strand and an antisense strand forming a double stranded region, wherein the antisense strand comprises a region of complementarity to an mRNA encoding PRODH2, and wherein the region of complementarity comprises at least 15 contiguous nucleotides differing by no more than 3 nucleotides from any one of the antisense nucleotide sequences in any one of Tables 2-3;
• or
• c) wherein the dsRNA agent comprises a sense strand and an antisense strand forming a double stranded region, wherein the sense strand comprises at least 15 contiguous nucleotides differing by no more than 3 nucleotides from any one of the nucleotide sequence of nucleotides 47-69, 262-284, 273-295, 545-567, 611-633, 655-677, 942-964, 949-971, 1119-1141, 1173-1195, 1183-1205, 1215-1237, 1243-1265, 1249-1271, 1254-1276, 1354-1376, 1436-1458, and 1444-1466 of SEQ ID NO:1, and the antisense strand comprises at least 15 contiguous nucleotides from the corresponding nucleotide sequence of SEQ ID NO:
• 2.