Cancer-specific polypeptide and use thereof
AssigneeThe Catholic University of Korea Industry-Academic Cooperation Foundation
InventorsJae Myung PARK, Moon Hwa KWAK
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Abstract
An aspect relates to a cancer-specific polypeptide consisting of an amino acid sequence of SEQ ID NO: 1. The polypeptide according to an aspect may bind specifically to LGR5 protein expressed in a tumor tissue, and when binding to a labeling material (for example, a fluorescent material), a cancer that expresses the LGR5 protein may be diagnosed. Furthermore, when the polypeptide binds to an isotope, a metastatic tumor may be also diagnosed. When the polypeptide according to an aspect binds to a photosensitizer and is then administered to a subject, the photosensitizer may be activated through light irradiation so that cancer cells may be killed, thereby enabling the prevention, amelioration, or treatment of cancer.
Claims23
-23. (canceled)
A method of diagnosing a cancer, the method comprising:
- administering a composition comprising a polypeptide having an amino acid sequence of SEQ ID NO:
- 1 to a subject;
- and
- confirming a position of the polypeptide in the subject.
A method of preventing or treating a cancer, the method comprising:
- administering a composition comprising a polypeptide having an amino acid sequence of SEQ ID NO:
- 1 to a subject in need thereof;
- and
- irradiating the subject with light.
Dependencies are inferred from the claim text.