Extracranial Methods For Facilitating Cerebrospinal Fluid Drainage
AssigneesInstitute for Basic Science (IBS), Korea Advanced Institute of Science and Technology
InventorsJin-Hui Yoon, Hokyung Jin, Ji Hoon Ahn, Seon Pyo Hong, Myung Jin Yang, Gou Young Koh
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Abstract
Described herein is a method of preventing or treating a neurodegenerative disease including administering an agent to a person in which the agent causes increase in outflow of cerebrospinal fluid through nasopharyngeal lymphatic plexus (NPLP), or an agent that causes contraction and relaxation of the circular smooth muscles covering the deep cervical lymphatic vessels (dcLVs).
Claims21
A method of increasing outflow of cerebral spinal fluid (CSF) from central nervous system comprising repairing or enlarging nasopharyngeal lymphatic plexus (NPLP) comprising:
- determining a subject in need of increased CSF outflow;
- and
- administering an effective amount of NPLP flow agent to the subject in need, whereby the amount of the agent repairs or enlarges NPLP of the subject, thereby increasing CSF outflow from the central nervous system to systemic circulation in the subject.
A method of increasing outflow of cerebral spinal fluid (CSF) from central nervous system comprising increasing contracting-relaxing of dcLV comprising:
- determining a subject in need of increased CSF outflow;
- and
- administering an effective amount of dcLV flow agent to the subject, whereby the amount increases contracting-relaxing of dcLV of the subject, thereby increasing CSF flow from the central nervous system to systemic circulation in the subject.
A method of preventing or treating or ameliorating a neurodegenerative disease or condition in a subject comprising repairing or enlarging nasopharyngeal lymphatic plexus (NPLP) comprising:
- determining the subject in need of increased CSF outflow from the central nervous system;
- and
- administering an effective amount of NPLP flow agent to the subject in need, whereby the amount of the agent repairs or enlarges NPLP of the subject, thereby increasing CSF outflow from the central nervous system to systemic circulation in the subject.
-40. (canceled)
Dependencies are inferred from the claim text.