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US 2024/0207187 A1Published application
Dendritic architectures as nonviral vectors in gene delivery
AssigneeTIBA Biotech LLC
InventorsPoulami TALUKDER, Karl RUPING
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Abstract
Disclosed herein are novel dendritic structures that can be used in combination with other lipid components to form nanoparticles with nucleic acids. to facilitate the intracellular delivery of nucleic acids both in vitro and in vivo. Nanoparticle compositions comprising the compounds and methods for their use for treating or preventing diseases or conditions are also provided.
Claims25
A nucleic acid carrier comprising a dendron or dendrimer of Formula Ia, Ib, Ic, Id, Ie, or If:
- wherein PE is a polyester dendron, which includes a core and a plurality of monomeric polyester units that form one or more generations, A is an amine, B is a hydrophobic unit, and z is the number of surface groups.
-13. (canceled)
-21. (canceled)
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- 45. (canceled)
Dependencies are inferred from the claim text.