Androgen receptor modulators

A compound or pharmaceutically acceptable salt thereof, wherein the compound has a structure corresponding to Formula (V-A1), Formula (V-B1), Formula (V-C1), or Formula (V-D1):

• wherein the A ring is an unsaturated, partially saturated, or saturated carbocyclic or heterocyclic ring containing 5 or 6 ring atoms;
• m is an integer selected from the group consisting of 0, 1, 2, and 3;
• n is an integer selected from the group consisting of 0, 1, 2, 3, 4, 5, 6, 7, and 8;
• each RA is independently selected from the group consisting of hydrogen, C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C1-10-haloalkyl, halogen, oxo, —ORAX, —SRAY, —S(O)2NRZ1RZ2, —S(O)2RZ1, —S(O)RZ1, —NRZ1RZ2, —N(RZ1)C(O)RZ2, —N(RZ1)S(O)2RZ2, C6-10-aryl, and 5- to 10-membered heteroaryl,
• wherein RAX is hydrogen, C1-6-alkyl, C2-10-alkenyl, C2-10-alkynyl, C1-10-haloalkyl, —C(O)—C1-10-alkyl, —C(O)—C6-10-aryl, —C(O)-heteroaryl, —C(O)—O—C1-10-alkyl, —C(O)—O—C6-10-aryl, —C(O)—O-heteroaryl, —C(O)—NRZ1RZ2, —S(O)2NRZ1RZ2, —S(O)2RZ1, C6-10-aryl, or 5- to 10-membered heteroaryl,
• wherein RAY is hydrogen, C1-6-alkyl, C2-10-alkenyl, C2-10-alkynyl, C1-10-haloalkyl, —C(O)—C1-10-alkyl, —C(O)—C6-10-aryl, —C(O)-heteroaryl, C6-10-aryl, or 5- to 10-membered heteroaryl,
• wherein each of RZ1 and RZ2 are independently hydrogen, C1-6-alkyl, C2-10-alkenyl, C2-10-alkynyl, C1-10-haloalkyl, —(CH2)m—C6-10-aryl, —(CH2)m-5- to 10-membered heteroaryl, hydroxy, or C1-6-alkoxy;
• each of R6A and R6B are independently absent or selected from the group consisting of hydrogen, C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C1-10-haloalkyl, and halogen;
• each of R7A and R7B are independently selected from the group consisting of hydrogen, C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C1-10-haloalkyl, halogen, hydroxy, and oxo;
• R10 is A-XA-RX,
• wherein A is a C1-C14-alkylene, C1-C14-haloalkylene, C2-C14-alkenylene, C2-C14-haloalkenylene, C2-C14-alkynylene, C2-C14-haloalkynylene, each of which is optionally interrupted by one or more of —O—, —NRZ—, —C(O)—, —C(O)O—, —OC(O)—, —C(O)NRZ—, —NRZC(O)—, —S(O)y—, —S(O)yNRZ—, —NRZS(O)y—, —C(S)NRZ—, —NRZC(S)—, C6-10-aryl, or 5- to 10-membered heteroaryl;
• XA is absent or selected from the group consisting of —O—, —NRZ—, —C(O)—, —C(O)O—, —OC(O)—, —C(O)NRZ—, —NRZC(O)—, —S(O)y—, —S(O)yNRZ—, —NRZS(O)y—, —C(S)NRZ—, —NRZC(S)—, C6-10-aryl, and 5- to 10-membered heteroaryl;
• RX is selected from the group consisting of hydrogen, C1-6-alkyl, C1-6-haloalkyl, C2-6-alkenyl, C2-6-haloalkenyl, C2-6-alkynyl, C2-6-haloalkynyl, C3-7-cycloalkyl, —C(O)—C1-6-alkyl, —C(O)—C6-10-aryl, —C(O)-heteroaryl, —C(O)—NRZ1RZ2, —S(O)2NRZ1RZ2, —NRZ1RZ2, —N(RZ1)C(O)RZ2, —N(RZ1)S(O)2RZ2, —C6-10-aryl, and 5- to 10-membered heteroaryl;
• wherein RZ is hydrogen, C1-6-alkyl, C1-6-haloalkyl, C2-6-alkenyl, C2-6-haloalkenyl, C2-6-alkynyl, C2-6-haloalkynyl, C3-7-cycloalkyl, C6-10-aryl, or 5- to 10-membered heteroaryl and y is 0, 1, or 2;
• R13 is selected from the group consisting of C1-C14-alkyl, C1-C14-haloalkyl, C2-C14-alkenyl, C2-C14-haloalkenyl, C2-C14-alkynyl, C2-C14-haloalkynyl, each of which is optionally interrupted by one or more of —O—, —NRZ—, —C(O)—, —C(O)O—, —OC(O)—, —C(O)NRZ—, —NRZC(O)—, —S(O)y—, —S(O)yNRZ—, —NRZS(O)y—, —C(S)NRZ—, —NRZC(S)—, —(CH2)m—C6-10-aryl, and —(CH2)m-5- to 10-membered heteroaryl;
• W, together with carbon atoms C14 and C15, forms a C3-C7-carbocycle or a 3- to 7-membered heterocycle and wherein the C3-C7-carbocycle or 3- to 7-membered heterocycle is optionally substituted with one or more halogen, hydroxy, C1-6-alkyl, C1-6-haloalkyl, or C1-6-alkoxy;
• R15B is selected from the group consisting of hydrogen, C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C1-10-haloalkyl, and halogen;
• R16 is selected from the group consisting of oxo and —ORD, wherein RD is selected from the group consisting of hydrogen, C1-10-alkyl, C1-10-haloalkyl, C2-10-alkenyl, C2-10-haloalkenyl, C2-10-alkynyl, C2-10-haloalkynyl, —(CH2)m-C6-10-aryl, —(CH2)m-5- to 10-membered heteroaryl, —C(O)—C1-10-alkyl, —C(O)—C1-10-haloalkyl, —C(O)—C2-10-alkenyl, —C(O)—C2-10-haloalkenyl, —C(O)—C2-10-haloalkynyl, —C(O)—(CH2)m—C6-10-aryl, —C(O)—(CH2)m-5- to 10-membered heteroaryl;
• each of R17A and R17B are independently selected from the group consisting of hydrogen, C1-10-alkyl, C2-10-alkenyl, C2-10-alkynyl, C1-10-haloalkyl, halogen, hydroxy, C1-6-alkoxy, C1-10-alkyl-C(O), —C(O)—C1-10-alkyl, —C(O)—C1-10-hydroxyalkyl, —C(O)—C1-10-alkyl-C6-10-aryl, —C(O)—C1-10-alkyl-heteroaryl, —C(O)—C6-10-aryl, —C(O)-heteroaryl, —O—C(O)—C1-6-alkyl, C6-10-aryl, and 5- to 10-membered heteroaryl, or R17A and R17B together form an oxo;
• and
• each independently represents a single bond or a double bond, provided that provided that if the bond between carbon C5 and carbon C6 is a double bond, then one of R6A or R6B is absent;
• wherein any C6-10-aryl or 5- to 10-membered heteroaryl is optionally substituted with one or more halogen, hydroxy, C1-6-alkyl, C1-6-haloalkyl, or C1-6-alkoxy.