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US 2024/0199534 A1Published application
Cyclopropane analogues of n-(trans-4-hydroxycyclohexyl)-6-phenylhexanamide and related compounds
OwnerGerald W. DORN, IIinventor
Life of this patent
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Abstract
The present disclosure relates to compounds of Formula (I): or pharmaceutically acceptable salts thereof. The present disclosure also relates to uses of the compounds, e.g., in treating or preventing diseases, disorders, or conditions (e.g., associated with mitochondria).
Claims30
A compound of Formula (I):
- or a pharmaceutically acceptable salt thereof, wherein
- T is absent, C1-C5 alkylene, or 2- to 5-membered heteroalkylene, wherein the C1-C5 alkylene or 2- to 5-membered heteroalkylene is optionally substituted with one or more RT;
- each RT independently is halogen, cyano, —ORT1, —N(RT1)2, oxo, C1-C10 alkyl, or C3-C10 cycloalkyl;
- or two RT, together with the atom they attach to, form C3-C10 cycloalkyl or 3- to 10-membered heterocycloalkyl;
- each RT1 independently is H or C1-C6 alkyl;
- X is C2-C5 alkylene or 2- to 5-membered heteroalkylene, wherein the C2-C5 alkylene or 2- to 5-membered heteroalkylene is optionally substituted with one or more RX;
- each RX independently is halogen, cyano, ORX1, —N(RX1)2, oxo, C1-C10 alkyl, or C3-C10 cycloalkyl, or two RX, together with the atom they attach to, form C3-C10 cycloalkyl or 3- to 10-membered heterocycloalkyl;
- each RX1 independently is H or C1-C6 alkyl;
- R is C6-C10 aryl or 5- to 10-membered heteroaryl, wherein the C6-C10 aryl or 5- to 10-membered heteroaryl is optionally substituted with one or more halogen, cyano, —ORS, —N(RS)2, C1-C10 alkyl, or C3-C10 cycloalkyl;
- and
- each RS independently is H or C1-C6 alkyl.
8 more elements
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(canceled)
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Dependencies are inferred from the claim text.